First, this version has only been approved for a small number of circumstances. An individual would need to prove that they fell into one of the following categories before they would be approved to receive the prescription injectable human growth hormone:
Human Growth Hormone Deficiency - As previously described, this is a condition in which an individual, usually diagnoses as a child, is not capable of producing enough human growth hormone on their own. This may be related to a congenital defect that was present before birth or due to some situation, such as a brain tumor or surgery, that damaged the pituitary gland at some later point in life..
Turner’s Syndrome -Turner’s syndrome is a human genetic abnormality that is present in females. In this situation, the affected female has only one functioning X chromosome, instead of two. Symptoms include short stature, swelling of the hands and feet, low hairline and low set ears, problems with infertility. Although more rare, other symptoms of this syndrome include a small lower jaw, turned out elbows and soft, upturned nails. The affected individual may also experience hearing loss and pigmented moles. This syndrome and its symptoms vary widely among patients. The syndrome occurs in about 1 of every 2,500 births.
Chronic renal insufficiency- This is a slowly progressive loss of renal function. It may occur over a period of months or even years. This means that the kidneys slowly lose their ability to dispose of waste, concentrate urine, as well as conserve salt and water; a critically important role. The kidneys also have a role in the growth process and when the kidneys begin to malfunction, the growth process can be compromised and growth failure may result. Patients may only be able to recover through a kidney transplant, as the condition is considered to be irreversible; however this presents a major problem in the case of children who may have already sustained significant damage due to the interruption of the growth process. In these situations, growth hormone therapy is usually added as part of the treatment regimen.
Intrauterine growth retardation -This is a condition during pregnancy in which a fetus is thought to be too small for its gestational age. This may be determined either from viewing an ultrasound or from measuring the mother’s abdomen at various points during the pregnancy. While there may be a number of causes for intrauterine growth retardation, it simply means that the baby is failing to grow inside the womb before it is ever born. This can lead to serious complications and threaten the success of the pregnancy.
Height deficit at or after puberty -This refers to a situation in which an individual is considered to be shorter than the average for their gender after they have already passed puberty, and presumably their growth phases.
Prader-Willi syndrome -This is a genetic disorder in which some seven genes on Chromosone 15 are actually missing or even unexpressed. The condition may be recognized by feeding difficulties during infancy, and may continue into childhood and adulthood with such symptoms as overeating and morbid obesity. There is usually some degree of mental retardation and behavior difficulties present as well. It is common for patients with this syndrome to also have short stature and hypothyroidism.
Research Paper Index