Growth Hormone (GH) Dosing during Catch-Up Growth Guided by Individual Responsiveness Decreases Growth Response Variability in Prepubertal Children with GH Deficiency or Idiopathic Short Stature

Click here to buy the human growth hormone product recommended by EternalHGH.com.

Berit Kriström, A. Stefan Aronson, Jovanna Dahlgren, Jan Gustafsson, Maria Halldin, Sten A. Ivarsson, Nils-Östen Nilsson, Johan Svensson, Torsten Tuvemo, and Kerstin Albertsson-Wikland

Journal of Clinical Endocrinology & Metabolism 94: 483-490; published online before print as doi:10.1210/jc.2008-1503

The purpose of this 2 year study was to test the hypothesis that individualized growth hormone doses, based on variation in GH responsiveness estimated by a prediction model, reduced variability in growth response around a set height target compared with a standardized weight-based dose. Growth hormone dosing based on weight results in a wide variation in growth response in children with GH deficiency (GHD) or idiopathic short stature (ISS).

This multicenter study included 153 short prepubertal children diagnosed with isolated GHD or ISS and at least 1 standard deviation score (SDS) below mid-parental height SDS. The children were randomized to receive either a standard (43 µg/kg · d) or individualized (17–100 µg/kg · d) GH dose.

The study concluded that individualized GH doses during catch-up growth significantly reduce the proportion of unexpectedly good and poor responders around a predefined individual growth target and result in equal growth responses in children with GHD and ISS.

Start your all natural hGH supplemementation today. Click here to get started.