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W. Matthew Widdowson and James Gibney
J. Clin. Endocrinol. Metab.,
Nov 2008; 93: 4413 - 4417.
The purpose of this meta-analysis was to
determine the effects of growth hormone (GH) replacement on exercise
performance. GH replacement in GH-deficient adults exerts clear effects on body
composition, but there is a lack of high-quality evidence concerning its
functional effects.
The reviewers searched MEDLINE and reference lists of
included studies and relevant review articles. They selected 11 randomized,
double blind, placebo controlled studies that provided data pertaining to
patient numbers, study design, GH dose, age, IGF-I levels, and exercise
variables (maximal oxygen uptake and maximal power output).
Growth
hormone replacement was associated with significant improvement in maximal power
output and maximal oxygen uptake. There was no association between age or GH
dose on the degree of improvement.
The reviewers concluded that there is
strong evidence that growth hormone replacement improves exercise performance in
GH-deficient patients. This evidence should be considered when decisions are
made regarding prescription of GH.
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