Efficacy of Selected Treatments of HIV Wasting: A Systematic Review and Meta-Analysis.

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Graeme Moyle, Karen Schoelles, Kyle Fahrbach, Diana Frame, Kimberly James, Rachel Scheye, Nancy Cure-Bolt

J Acquir Immune Defic Syndr. 2004 Dec 1; 37 :S262-S276 15722869 (P,S,G,E,B)

The purpose of this review was to assess the efficacy of recombinant human growth hormone (rhGH), testosterone, and anabolic steroids in the treatment of HIV wasting. The reviewers searched the literature for studies published in English since 1996. The 18 studies selected included studies of anabolic steroids, testosterone, and rhGH in the treatment of HIV wasting that reported the efficacy outcomes of body composition measures, work output, or health-related quality of life.

Treatment with rhGH, testosterone, and anabolic steroids all demonstrated significant efficacy in increasing lean body mass compared with placebo. The reviewers concluded that the FDA approved dose of rhGH may have advantages over the other two therapies in terms of improvements in functional capacity and quality of life..



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