In cases where the deficiency was present from birth and was in fact congential, it is believed that the situation most likely occurred from a mutation related to a specific gene or set of genes. Intracranial tumors can also cause a deficiency of the human growth hormone. In some cases surgery is required to remove the tumor and if in doing so the pituitary gland is disturbed, damaged or partially removed then a growth hormone deficiency may occur. Radiation therapy, which is often used to treat a wide variety of illnesses, functions by controlling malignant cells. Should the pituitary gland be damaged during the radiation therapy, most commonly used in this area for treatment of leukemia and brain tumors, then the patient may have a human growth hormone deficiency which will then need to be treated with HGH therapy and supplements. A hemorrhage in the pituitary region due to low blood pressure, which is known as Sheehan Syndrome, has also been linked to acquired human growth hormone deficiency issues.
If it is determined that a deficiency does exist, the patient will generally be treated with what is known as Somatotropin Replacement Therapy. In optimal cases, SRT will be able to restore energy and metabolism to the patient, resulting in a return to normal body composition.
Approval for the use of a human growth hormone therapy treatment for adults was given by the FDA on August 8, 1996 .
It is anticipated that the future of human growth hormone may also lie in treatments for burn and surgery victims as well as usage in AIDS research.
In recent years there has also been tremendous controversy over the usage of human growth hormone by athletes hoping to increase their strength and muscle mass. Generally, human growth hormone is unable to be detected by most drug tests. While some studies have concluded that HgH has absolutely no effect on the increase of strength or body fat many athletes continue to pursue ways to boost their performance. In addition, some studies have also shown that there are significant side effects related to the use of the human growth hormone. These side effects include joint pain and carpal tunnel syndrome.
Since homeopathic human growth hormone was approved by the FDA, there has been an explosion of black market usage and it is now promoted for a variety of health cures. Besides its use in athletes, human growth hormone is also often promoted as an anti-aging product.
On July 26, 2003 ; the FDA approved an expanded use of the injectable form of rGH. This drug application is produced by Eli Lilly and Company for the treatment of adults and children who appear to be unusually short. In adults, the drug is only approved for men who less than 5 feet, 3 inches in height and women who are less than 4 feet, 11 inches in height. The approval of this drug is very exciting because it makes it possible for individuals who appear to suffer from some type of human growth hormone deficiency, but who have been unable to prove it in the past in order to obtain approval for use of the former human growth hormone drug due to the fact that deficiencies are often difficult to detect.
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