The effect of rhGH on height velocity and BMI in children with CKD: a report of the NAPRTCS registry.

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Seikaly MG, Waber P, Warady BA, Stablein D
University of Texas Southwestern Medical Center

Pediatr Nephrol. 2009 Apr 23

The purpose of this review was to evaluate the impact of recombinant human growth hormone (rhGH) therapy on height velocity (HV), estimated glomerular filtration rate (eGFR) and body mass index (BMI) in children with chronic kidney disease (CKD).

The reviewers examined longitudinal data from patients enrolled in the chronic renal insufficiency registry of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS). 11.5% of the 7189 patients enrolled in the registry had received rhGH.

The review included 787 children with CKD who received rhGH for 1-4 years. They were paired with 787 control patients, matched for age, gender, height and length of time in the NAPRTCS registry. The pairs were compared for HV, eGFR and BMI. Height velocity was also compared to the general U.S. population.

The group treated with recombinant human growth hormone had a significantly greater height velocity standard deviation score (SDS) than the control group at each 6-months post-rhGH treatment initiation point for 2.5 years. Among 220 pairs at 2 years, the height SDS of the rhGH group was 0.56 SDS higher than that of the control group. Treatment with rhGH had no significant impact on the BMI or eGFR.

The review concluded that recombinant human growth hormone therapy is associated with improved height velocity in children with chronic kidney disease, but it does not appear to have any impact on BMI or kidney function.



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