One important question with growth hormone use, especially in children, is what the long term effects are. Is it possible that short term positive effects could lead to long term negative effects? This is what this study has tried to analyze.
Over the past 21 years a study was conducted on nearly 55,000 children who had growth hormone treatment. It was done by the National Cooperative Growth Study.
This was a fairly simple study. Children were watched until their growth hormone use was discontinued. Adverse events were reported along with anything that could be related to rhgh.
Now there were at one point concerns that leukemia may have a higher chance of occurring in those who took HGH. However, there were actually less cases of leukemia in the growth hormone treated group than in a similar untreated population, which appears to put that claim to rest.
Type 1 diabetes also had a lower number of occurrences in this group than expected.
There was one area where rhgh seemed to cause things to be slightly worse - it increased the risk of a second tumor in those who had the first treated with irradiation.
The overall safety rating given was positive, while the researchers noted that in specific cases rhgh may cause slight increases in problems.
Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2009-0178
The Journal of Clinical Endocrinology & Metabolism Vol. 95, No. 1 167-177
Copyright © 2010 by The Endocrine Society
Long-Term Safety of Recombinant Human Growth Hormone in Children
J. Bell, K. L. Parker, R. D. Swinford, A. R. Hoffman, T. Maneatis and B. Lippe
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